About Protein Sequence Analyzer

PSA (Protein Sequence Analyzer) computes various Physico-chemical properties of proteins deducible from their primary sequences. PSA goes beyond just taking only one sequence at a time. Rather, it takes multiple protein sequences (or an ensemble/group of sequences) and provides distributions of the calculated properties. There is no limit on the number of sequences that can be processed, however, computation time may vary depending on the availability of computing resources at that time.

PSA works on MSA (Multiple Sequence Alignment) data and can be used to calculate various position-specific properties from the MSA data of proteins. This includes position-wise entropy, consensus sequence, elements of the Mutual Information (MI) matrix for co-evolution studies.

PSA can also be used to filter sequences from a group of sequences based on keywords (string) in the header of the sequences, sequence length, and presence of a character (ambiguous character) in the sequence.

In summary, PSA is most useful to study a group of proteins by calculating the amino acids composition, propensities, and other sequence-related properties. Protein sequences from different organisms, sequences from different functional or structural categories of proteins, mutations-conservation-coevolution of amino acids are examples of some areas where PSA can be used.

For more details, check the  Tutorial  section

Jobs can be submitted to the server by clicking the  Submit  tab